Nexium (Esomeprazole)

Name: Nexium
Brand: AstraZeneca
SKU: 1767
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Nexium Sachets

Manufacturer: AstraZeneca

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Nexium Sachets

Manufacturer: AstraZeneca

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Nexium Tablet

Manufacturer: AstraZeneca

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Nexium Tablet

Manufacturer: AstraZeneca

Country: India

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Nexium Tablet

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Nexium Tablet

Manufacturer: AstraZeneca

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Nexium Tablet

Manufacturer: AstraZeneca

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Nexium Tablet

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Nexium Tablet (ON BACKORDER)

Manufacturer: AstraZeneca

Country: United Kingdom

Dosage: 40 mg

Qty-Price (USD):

Generic Equivalent of Nexium

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Esomeprazole Capsule

Manufacturer: Generic

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Esomeprazole Tablet

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Esomeprazole Tablet (Nexpro - Torrent Pharma)

Manufacturer: Generic

Country: India

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Esomeprazole Capsule

Manufacturer: Generic

Country: United Kingdom

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Esomeprazole Tablet

Manufacturer: Generic

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Nexium Information

medically reviewed by Carol Hou (BSc. Pharm) on July 31, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Nexium and Esomeprazole at CanadaPharmacyOnline.com

Nexium (esomeprazole) is manufactured by AstraZeneca and is widely available in many regions, including Canada, the United Kingdom, and Turkey. In India, it is sold under the brand name Neksium.

Generic esomeprazole, sourced from manufacturers meeting applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Nexium:

Generic esomeprazole contains the same active ingredient as brand-name Nexium and must meet the same safety, effectiveness, and quality standards. This means it's designed to work identically to Nexium. Studies have shown bioequivalence between generic and brand-name esomeprazole, indicating comparable absorption rates and overall effects. However, individual responses can vary. If you have questions about using generic esomeprazole, speak with your doctor or pharmacist. For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

Nexium and generic esomeprazole are available in various oral delayed-release formulations, including capsules and sachets/packets (powder for oral suspension). Common strengths available are:
• 10 mg
• 20 mg
• 40 mg

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Nexium (esomeprazole) is a prescription medication used to treat a variety of gastrointestinal conditions, including:
• Duodenal Ulcer and Gastric Ulcer: Treatment of these types of ulcers.
• Helicobacter pylori Eradication: Used in combination with antibiotics to eliminate H. pylori bacteria, a common cause of stomach ulcers.
• Maintenance of Healing of Erosive Esophagitis: To keep the esophagus healed and prevent relapse of heartburn symptoms in adults with GERD.
• Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome: Long-term treatment for conditions where the stomach produces excessive acid.
• Prevention of Gastric Ulcers Induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): For patients at increased risk of developing upper gastrointestinal lesions while on continuous NSAID therapy.
• Short-Term Treatment of Erosive Esophagitis Associated with Gastroesophageal Reflux Disease (GERD): Healing and symptomatic relief of esophageal damage caused by stomach acid.
• Symptomatic Gastroesophageal Reflux Disease (e.g., acid regurgitation and heartburn): Relief of these symptoms.

Mechanism of Action
Nexium (esomeprazole) is a proton pump inhibitor (PPI). It works by irreversibly binding to the H+/K+-ATPase enzyme system, also known as the proton pump, located on the secretory surface of the gastric parietal cells in the stomach. This enzyme is the final step in the production of gastric acid. By blocking this pump, esomeprazole effectively suppresses both basal (constant) and stimulated (triggered by food) gastric acid secretion, regardless of the stimulus. Since the binding is irreversible, new proton pumps must be synthesized before acid production can resume, providing a sustained anti-secretory effect that can last over 24 hours.

Always take Nexium exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Nexium, it's crucial to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Nexium, it's crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Nexium; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain
• Constipation
• Diarrhea
• Dizziness
• Dry mouth
• Flatulence (gas)
• Headache
• Nausea
• Vomiting

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, wheezing, and itching.
• Bone fracture: Increased risk of hip, wrist, or spine fractures, especially with high doses or long-term use (one year or more).
• Clostridium difficile-associated diarrhea (CDAD): Severe, watery diarrhea that doesn't improve, fever, abdominal pain. The risk is increased with the use of PPIs.
• Hypomagnesemia (low magnesium levels in the blood) is characterized by symptoms such as muscle spasms, tremors, irregular heartbeat, seizures, or dizziness. More common with prolonged use (three months or more).
• Kidney problems (Acute Interstitial Nephritis): Signs include changes in urination frequency or amount, blood in urine, fever, joint pain, loss of appetite, nausea, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or unusual weight gain.
• Lupus erythematosus (cutaneous or systemic): New or worsening joint pain, skin rash on cheeks or arms that worsens in sunlight.
• Microscopic Colitis: May cause or worsen symptoms such as watery diarrhea with abdominal pain, especially after several weeks or months of treatment.
• Polyps: Long-term use may cause growths (polyps) in the stomach, specifically fundic gland polyps. These are usually not cancerous and often don't cause symptoms, but can become more common with prolonged PPI use.
• Risk of Cardiovascular Events: While not conclusively established as a causal link, some observational studies have suggested a possible increased risk of major cardiovascular events (e.g., heart attack) with specific PPIs, particularly in patients with pre-existing heart conditions or those taking clopidogrel. Discuss this concern with your doctor.
• Severe Skin Reactions: Redness, blistering, peeling, or loosening of the skin, including inside the mouth (e.g., Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS)).
• Vitamin B12 deficiency: Long-term use (more than three years) may lead to vitamin B12 deficiency. Symptoms can include numbness or tingling in the hands or feet, muscle weakness, confusion, or memory problems.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Nexium, it's crucial to discuss all your medical conditions, past and present, and all medications you're taking with your doctor or pharmacist.

Nexium should not be used if:
• You are allergic to esomeprazole, other substituted benzimidazoles (like other PPIs), or any other ingredient in Nexium. • You are taking rilpivirine (an antiretroviral drug). Concomitant use is contraindicated.

Tell your doctor about all of your medical conditions, past and present, before starting Nexium. This is crucial because certain conditions affect whether Nexium is right for you. These conditions may include, but aren't limited to:
• Any unusual or allergic reaction to esomeprazole or other medications
• Heartburn with lightheadedness, sweating, or dizziness (may indicate a more serious condition)
• History of low magnesium levels (hypomagnesemia)
• History of seizures
• If you have diarrhea, especially if it's severe or persistent
• Kidney problems
• Liver disease (may require dose adjustment)
• Osteoporosis and risk factors for bone fractures
• Systemic lupus erythematosus (SLE) or other autoimmune conditions
• Unexplained weight loss, frequent chest pain, frequent wheezing (particularly with heartburn), nausea or vomiting, or stomach pain, especially if accompanied by difficulty swallowing or blood in vomit/stools (could be signs of a serious underlying condition, such as esophageal or stomach cancer, which Nexium might mask).

Drug Interactions

Before taking Nexium, it's essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official product monograph | AstraZeneca.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It's also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you're making, as these could potentially interact with Nexium. Nexium may interact with other medicines, but is not limited to:
• Antiretroviral drugs (e.g., atazanavir, nelfinavir, rilpivirine): Nexium can significantly reduce the absorption of certain antiretrovirals, making them less effective. Concomitant use with rilpivirine is contraindicated.
• Clopidogrel (antiplatelet): Nexium may reduce the effectiveness of clopidogrel (due to inhibition of CYP2C19, an enzyme involved in clopidogrel activation). Your doctor may consider an alternative acid-reducing medication or an alternative antiplatelet if a PPI is necessary.
• Diazepam, Phenytoin, Cilostazol: Esomeprazole can increase blood levels of these medications (due to inhibition of CYP2C19).
• Digoxin: Increased absorption of digoxin can occur.
• Diuretics (thiazide or loop diuretics): Increased risk of hypomagnesemia.
• Drugs that depend on gastric pH for absorption (e.g., ketoconazole, itraconazole, erlotinib, iron salts, ampicillin esters, mycophenolate mofetil): affected by Nexium, which decreases stomach acid, potentially reducing their absorption and effectiveness.
• Methotrexate: Concomitant use, especially with high-dose methotrexate, may increase methotrexate levels and its toxicity. A temporary withdrawal of the PPI may be considered.
• St. John's Wort: May reduce the effectiveness of esomeprazole.
• Tacrolimus: Increased systemic exposure of tacrolimus has been reported with concomitant PPI use.
• Voriconazole: May increase esomeprazole exposure.
• Warfarin (blood thinner): Increased risk of bleeding. Close monitoring of INR (International Normalized Ratio) is recommended.

Pregnancy and Breastfeeding

Nexium should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. While studies generally indicate safety, consult your doctor if you're pregnant or planning to become pregnant. Esomeprazole is excreted in human milk. A decision should be made whether to discontinue breastfeeding or the drug, considering the importance of the drug to the mother. Consult your doctor for personalized advice.

Use in the Elderly

No overall differences in safety or effectiveness have been observed between elderly and younger patients. However, elderly patients may be at an increased risk for specific side effects, such as Clostridium difficile infection, bone density loss, and low magnesium levels. No dosage adjustment is typically needed based solely on age, but caution and close monitoring are advisable.

Use in Children

Nexium is indicated for short-term treatment of erosive esophagitis associated with GERD in pediatric patients aged 1 month and older (dosage varies by age and weight). It's also indicated for symptomatic GERD in children aged 1 year and older. The safety of treatment beyond 8 weeks in most pediatric indications has not been established. For specific age groups and conditions, use and dosage must be determined by a doctor.

Frequently Asked Questions about Nexium at Canada Pharmacy Online:

Why is Nexium more affordable in Canada than in the United States?

Prescription drug prices, including Nexium, are generally lower in Canada than in the US. This is due to various factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, often resulting in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Nexium at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Nexium (prescription strength) requires a valid prescription from your doctor. We do not sell this product without a valid prescription. Note that Nexium 24HR is available over-the-counter in certain regions for the treatment of frequent heartburn.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to take Nexium?

Nexium is typically taken once daily, at least one hour before a meal. It's important to swallow delayed-release capsules or tablets whole without crushing or chewing them. If you have trouble swallowing, the capsule can often be opened and sprinkled onto a tablespoon of applesauce, then swallowed immediately without chewing. Follow your doctor's specific instructions.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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