Estradot (Estradiol-17B)

Name: Estradot
Brand: Sandoz
SKU: 7430
Availability: InStock

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Country

Dosage

Qty-Price (USD)

Type:

Product: Estradot

Manufacturer: Sandoz

Country: Canada

Dosage: 25 mcg

Qty-Price (USD):

Type:

Product: Estradot

Manufacturer: Sandoz

Country: Canada

Dosage: 37.5 mcg

Qty-Price (USD):

Type:

Product: Estradot

Manufacturer: Sandoz

Country: Canada

Dosage: 50 mcg

Qty-Price (USD):

Type:

Product: Estradot

Manufacturer: Sandoz

Country: Canada

Dosage: 75 mcg

Qty-Price (USD):

Type:

Product: Estradot

Manufacturer: Sandoz

Country: Canada

Dosage: 100 mcg

Qty-Price (USD):

Generic Equivalent of Estradot

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Product

Manufacturer

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Qty-Price (USD)

Type:

Product: Estradiol-17B

Manufacturer: Generic

Country: Canada

Dosage: 100 mcg

Qty-Price (USD):

Estradot Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on May 12, 2025.

Estradot and Estradiol-17B at CanadaPharmacyOnline.com

The brand Estradot (estradiol-17B), manufactured by Sandoz in Canada.

Generic estradiol 17-B is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Estradiol-17B

Generic estradiol-17B contains the same active ingredient as brand-name Estradot and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Estradot. Studies demonstrated bioequivalence between generic and brand-name Estradot, demonstrating comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have any questions about using generic estradiol-17B.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Estradot (generic estradiol-17B) is available in the format of transdermal patches. Estradot has various strengths, including 25 mcg, 37.5 mcg, 50 mcg, 75 mcg, and 100 mcg. Generic estradiol-17B is currently only available in 100 mcg transdermal patches (at this pharmacy)

Usage:

Estradot is a prescription medication used to alleviate common menopausal symptoms like hot flashes, night sweats, and vaginal dryness. It is also used to help prevent osteoporosis, a post-menopausal condition. Estradot is typically prescribed alongside a progestogen to protect the uterine lining. (source: the product monograph | Novartis.com)

Mechanism of Action:
Estradot is an estrogen that delivers estradiol transdermally, enabling systemic absorption and bypassing first-pass hepatic metabolism. Estradiol exerts its effects by binding to intracellular estrogen receptors (ERα and ERβ), modulating gene transcription and subsequent protein synthesis. This mechanism underlies its therapeutic actions, including the alleviation of vasomotor symptoms by influencing hypothalamic thermoregulatory centers, the prevention of osteoporosis through inhibition of bone resorption, and the maintenance of urogenital tissue integrity. Additionally, estradiol can elicit rapid, non-genomic effects via membrane-bound estrogen receptors. In women with a uterus, concurrent progestogen administration is necessary to mitigate the risk of endometrial hyperplasia by opposing estrogen-mediated endometrial proliferation.

It is crucial to use Estradot exactly as your doctor prescribes and refer to Consumer Information | The Drug and Health Product Register (DHPR). Consult your doctor for personalized guidance and safe use.

Side effects:

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Estradot, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Common Side Effects – These are some frequently reported side effects of Estradot (estradiol), but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or if you experience any other concerning symptoms.
• Breast tenderness or pain
• Headaches
• Nausea
• Vaginal bleeding or spotting
• Mood changes
• Fluid retention/bloating
• Skin irritation
• Stomach cramps
• Weight gain

Serious or rare side effects: Stop taking Estradot and seek immediate medical attention if you experience any of the following.
• Blood clots: This can manifest as deep vein thrombosis (DVT), pulmonary embolism (PE), or stroke. Symptoms may include leg pain or swelling, chest pain, shortness of breath, sudden severe headache, vision changes, or slurred speech.
• Heart attack: Chest pain, shortness of breath, and pain radiating to the arm or jaw are key symptoms.
• Stroke: Sudden numbness or weakness, especially on one side of the body, confusion, trouble speaking or understanding, vision problems, and severe headache.
• Gallbladder disease: Severe abdominal pain, nausea, and vomiting.
• Endometrial cancer: Abnormal vaginal bleeding or spotting.
• Breast cancer: Changes in breast tissue, such as lumps, nipple discharge, or skin dimpling.
• Ovarian cancer: Pelvic or abdominal pain, bloating, feeling full quickly, and changes in bowel or bladder habits.
• High blood pressure: Severe headaches, dizziness, or blurred vision.
• Visual disturbances: Sudden partial or complete loss of vision, or sudden onset of proptosis, diplopia, or migraine.
• Severe allergic reactions: Hives, swelling of the face, lips, or tongue, and difficulty breathing

Individual reactions can vary. It is crucial to discuss potential side effects and risks with your doctor for a complete and up-to-date list.

Contraindications:

The following is not an exhaustive list of contraindications. It is crucial to discuss all of your medical conditions, past and present, and all the medications you are taking with your doctor or pharmacist before taking Estradot (estradiol).

Estradot (estradiol-17B) is CONTRAINDICATED in the following and should not be used if:
• Known or suspected breast cancer: Estrogen can stimulate existing breast cancer or increase the risk of developing it.
• Hypersensitivity: Known hypersensitivity to the active substance or to any of the excipients.
• Known or suspected estrogen-dependent malignant neoplasms (e.g., endometrial cancer): Like breast cancer, estrogen can promote the growth of these cancers.
• Undiagnosed abnormal genital bleeding: This must be investigated before any estrogen therapy is considered, as it could be a sign of cancer.
• Active or history of venous thromboembolism (VTE), such as deep vein thrombosis (DVT) or pulmonary embolism (PE): Estrogen significantly increases the risk of blood clots.
• Active or recent arterial thromboembolic disease (e.g., stroke, myocardial infarction): These conditions are also worsened by estrogen's pro-clotting effects.
• Known thrombophilic disorders (e.g., Protein C, Protein S, or antithrombin deficiency): These conditions heighten the risk of blood clots.

Inform your doctor if you have any of the following pre-existing medical conditions, as they may affect whether Estradot is right for you:
• Significant liver disease
• Porphyria: this condition can be exacerbated by estrogen use.

Drug Interactions:

Before taking Estradot, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete information about potential drug interactions, please refer to the product labeling information, https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206685Orig1s000Lbl.pdf

Enzyme-inducing drugs:
• Certain medications that induce liver enzymes (like rifampin, carbamazepine, phenytoin, and barbiturates) can increase the metabolism of estradiol, potentially reducing its effectiveness.

Other medications:
• Certain antifungal medications, and some antibiotics, can also affect the levels of estradiol in the body.
• Levothyroxine: Estradiol can affect thyroid hormone levels, so adjustments to thyroid replacement therapy may be necessary.
• Certain HIV medications.

Other Estrogen Modulators:
• Medications like tamoxifen, raloxifene, and fulvestrant, which also act on estrogen receptors, can have complex interactions with estradiol.

Tranexamic Acid and Fezolinetant:
• These medications are often listed as having interactions that are not recommended with estradiol.

Pregnancy or Breastfeeding:

Estradot is contraindicated in pregnancy due to potential fetal harm. While transdermal estradiol may have a lower impact on breast milk compared to other estrogen formulations, its use during breastfeeding is generally discouraged due to the potential for reduced milk quantity and quality. Therefore, Estradot should not be used during pregnancy, and its use during breastfeeding requires careful consideration and consultation with a healthcare provider.

Frequently Asked Questions about Estradot at Canada Pharmacy Online:

Why is Estradot more affordable in Canada than in the United States?

Prescription drug prices, including Estradot, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, visit our How to Order page.

Can I buy Estradot over the counter from you?

No, Estradot requires a prescription from your doctor. We are unable to sell this product without a valid prescription from your doctor.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Estradot?

Yes, there is a generic version from Canada.

How should I use this medication?

Apply the patch to your buttocks, lower back, lower abdomen, or hip, avoiding your breasts and the same skin site consecutively. Change the patch every 3 to 4 days, twice weekly on the same days, following your doctor's or product instructions or patient medical information. Important for women with a hysterectomy: Generally, you do NOT need to take progestin if using an estrogen-only patch. However, confirm this with your doctor or pharmacist for personalized guidance.

What should I do if I miss a dose?

If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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