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Inflectra (Infliximab)

Type
Product
Manufacturer
Country
Dosage
Qty-Price (USD)
Type: drug type
Product: Inflectra Vial - Local Pick Up Only
Manufacturer: Pfizer
Country: Canada
Dosage: 100 mg
Qty-Price (USD):

Generic Equivalent of Inflectra
Type
Product
Manufacturer
Country
Dosage
Qty-Price (USD)
There is no generic product of Inflectra.

Inflectra Information

Inflectra and Infliximab at CanadaPharmacyOnline.com

The manufacturer of brand-name Inflectra (infliximab) is Pfizer Inc. (developed in partnership with Celltrion, the original developer of this biosimilar). Inflectra was the first biosimilar monoclonal antibody to be approved by both Health Canada and the U.S. FDA, providing a high-quality alternative to the reference biologic, Remicade. This medication is available for Local Pick up Only.

The generic version is not available.

Dosage:

Inflectra is available in the following strengths:
• Injectable powder – 100 mg per single-use vial (to be reconstituted).

The dosage is calculated based on a patient's body weight. The standard adult dose is 5 mg/kg. Infusions are given at 0, 2, and 6 weeks. Maintenance infusions are typically every 8 weeks. However, your doctor may increase the dose or frequency based on your body’s response.

Usage:

Inflectra is used to treat several chronic inflammatory and autoimmune diseases. It is primarily indicated for Crohn's disease and ulcerative colitis (in both adults and children 6 years and older) when conventional therapies have not worked well enough. It is also used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and severe plaque psoriasis. Calming the body's overactive immune response helps reduce pain, swelling, and tissue damage, often leading to long-term remission.

Mechanism of Action
Infliximab is a tumor necrosis factor-alpha (TNF-α) inhibitor and a type of biologic disease-modifying antirheumatic drug (bDMARD). In many autoimmune diseases, the body produces excess TNF-α. This protein acts like an alarm, signaling the immune system to attack healthy tissues. Inflectra circulates in the blood and binds specifically to TNF-α proteins. Once Inflectra binds to these proteins, it neutralizes them, preventing them from signaling redness, swelling, and pain. This lowers the inflammation at the source, allowing the body's tissues to heal.

Inflectra is administered by slow IV infusion, usually taking about 2 hours, following the instructions in the product monograph. You will be monitored by medical staff during and after the infusion for any signs of a reaction.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Inflectra, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Inflectra (Infliximab). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Inflectra; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Fatigue
• Headache
• Infusion reactions (fever, chills, or rash during the drip)
• Nausea
• Stomach pain
• Upper respiratory infections (sinus infections, sore throat)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Heart Failure: New or worsening shortness of breath or swelling of the ankles.
• Liver Issues: Yellowing of the eyes/skin (jaundice) or dark urine.
• Lupus-like Syndrome: Joint pain or a rash on the cheeks/arms that worsens in the sun.
• Lymphoma/Cancer: Though rare, TNF-blockers have been associated with certain types of cancer.
• Serious Infections: Fever, persistent cough, or feeling very tired (biologics can increase the risk of serious infections).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Inflectra, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Inflectra/Infliximab if:
• Active Infections: Do not start Inflectra if you have a severe infection, such as an abscess or sepsis.
• Allergies: You have a known hypersensitivity to infliximab
• Heart Failure: It should not be used in patients with moderate-to-severe heart failure.
• Hepatitis B
• Tuberculosis

Tell your doctor about all of your medical conditions, past and present, before starting Inflectra. This is crucial as certain conditions affect the drug's safety.

Drug Interactions:

Before taking Inflectra, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://labeling.pfizer.com/showlabeling.aspx?id=9271.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Inflectra. Inflectra may interact with other medicines, including but not limited to:
• Live Vaccines: You should not receive live vaccines (such as MMR or FluMist) while on Inflectra, as the medication may allow the vaccine virus to multiply excessively.
• Other Biologics: Using Inflectra with other biologic medicines, such as Kineret (anakinra) or Orencia (abatacept), is not recommended due to a greatly increased risk of infection.

Pregnancy and Breastfeeding:

Inform your doctor if you are pregnant or planning to become pregnant. Infliximab crosses the placenta, especially during the third trimester. While it is often continued if the mother's disease is severe, it is important to notify the pediatrician, as the baby may need to delay live vaccinations for six months after birth. Infliximab is excreted in breast milk in very small amounts. It is generally considered compatible with breastfeeding, as the drug is a large protein that is likely destroyed in the infant's digestive tract.

Use in Children:

Inflectra is approved for use in children 6 years of age and older for the treatment of Crohn's disease and ulcerative colitis. Pediatric patients are closely monitored for growth and infection risk.

Frequently Asked Questions about Inflectra at Canada Pharmacy Online

Why is Inflectra more affordable in Canada than in the United States?

Prescription drug prices, including Inflectra, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Inflectra I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Inflectra per prescription from your doctor.

Can I buy Inflectra from you over the counter?

No, Inflectra requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Inflectra?

No, the generic infliximab is currently unavailable (at this pharmacy).

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Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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