Ranexa (Ranolazine)

Name: Ranexa
Brand: Kye Pharmaceuticals Inc.
SKU: 6571
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Ranexa

Manufacturer: Kye Pharmaceuticals Inc.

Country: Canada

Dosage: 500 mg

Qty-Price (USD):

Generic Equivalent of Ranexa

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Ranolazine

Manufacturer: Generic

Country: India

Dosage: 500 mg

Qty-Price (USD):

Type:

Product: Ranolazine

Manufacturer: Generic

Country: India

Dosage: 1000 mg

Qty-Price (USD):

Type:

Product: Ranolazine Tablet

Manufacturer: Generic

Country: India

Dosage: 1000 mg

Qty-Price (USD):

Ranexa Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on June 3, 2025.

Ranexa and Ranolazine Extended Release at CanadaPharmacyOnline.com

Brand Ranexa (ranolazine extended-release), manufactured by Kye Pharmaceuticals Inc., is available in Canada under the brand name Corzyna.

Generic ranolazine extended-release is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Ranolazine Extended-Release:

Generic ranolazine extended-release contains the same active ingredient as the brand-name Ranexa. It is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Ranexa. Studies have demonstrated bioequivalence between generic and brand-name ranolazine extended-release, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have questions about using generic ranolazine extended-release.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs

Dosage:

Brand Ranexa and generic ranolazine extended-release are commonly available 500 mg and 1000 mg extended-release tablets (at this pharmacy).

Your doctor will determine the appropriate dose based on your needs and medical condition.

Usage:

Ranexa (ranolazine extended-release) is a prescription medication used to treat chronic angina (chest pain) in adults. It is typically used in combination with other medications for angina. Ranolazine is not used to treat acute episodes of chest pain. Your doctor determines the dosage of ranolazine extended-release, which will depend on the severity of your condition and your individual needs. It is crucial to follow your doctor's prescribed dosing regimen (source: the product labeling information, https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021526s007lbl.pdf)

Mechanism of Action:
The mechanism of action of Ranexa (ranolazine) is not fully understood. However, ranolazine is known to inhibit the late sodium current (INa) in heart muscle cells at therapeutic concentrations. By inhibiting this current, ranolazine may reduce the intracellular sodium and calcium overload that occurs during ischemia (reduced blood flow to the heart), contributing to angina symptoms. Ranolazine's antianginal effects do not depend on reducing heart rate or blood pressure. This distinguishes its mechanism from other antianginal drugs like beta-blockers and calcium channel blockers, which primarily work by reducing heart rate or blood pressure. Ranolazine also has some inhibitory effects on the rapid delayed rectifier potassium current (IKr), which can prolong the QT interval on an electrocardiogram (ECG).

Take Ranexa orally exactly as your doctor prescribes, following the instructions in the patient information leaflet. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Ranexa, it is essential to discuss all possible aspects with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Ranexa, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects: These are examples of some common side effects of Ranexa, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Bradycardia (slow heart rate)
• Constipation
• Dizziness
• Headache
• Orthostatic hypotension (lightheadedness upon standing)
• Nausea
• Vomiting
• Weakness (asthenia)

Serious or rare side effects: Stop taking Ranexa and seek immediate medical attention if you experience any of the following:
• Allergic reactions (e.g., rash, itching, swelling, difficulty breathing)
• Angioedema (swelling of the face, lips, tongue, or throat)
• Changes in heart rhythm (e.g., fast, slow, or irregular heartbeat, palpitations, fainting)
• Changes in vision (e.g., blurred vision, double vision)
• Confusion
• Kidney problems (e.g., decreased urination, blood in urine, elevated creatinine, fatigue)
• Lightheadedness or fainting
• New or worsening shortness of breath
• QT interval prolongation on ECG

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Ranexa.

Ranexa should not be used if:
• You are taking strong inhibitors of CYP3A (a liver enzyme), such as ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, and saquinavir.
• You are taking strong CYP3A (a liver enzyme) inducers, such as rifampin, phenobarbital, phenytoin, carbamazepine, and St. John's Wort.
• You have a clinically significant liver impairment (e.g., liver cirrhosis).

Tell your doctor about all of your medical conditions, past and present, before starting Ranexa. This is crucial because certain conditions can affect whether Ranexa is right for you. These conditions may include, but are not limited to:
• A history of abnormal electrocardiogram (ECG) or QT prolongation (You may require ECG monitoring)
• Electrolyte imbalances (e.g., hypokalemia, hypomagnesemia)
• Heart failure
• Kidney disease (especially severe)
• Liver disease (mild to moderate)
• Low body weight (≤ 60 kg)
• Older age

Dizziness and Drowsiness:
Ranexa may cause dizziness. Do not drive, operate machinery, or engage in activities that require alertness until you understand how it affects you.

Drug Interactions:

Before taking Ranexa, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to Ranexa product information | European Medicines Agency: https://www.ema.europa.eu/en/documents/product-information/ranexa-epar-product-information_en.pdf

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Ranexa may interact with other medicines, including but not limited to CYP3A inhibitors (e.g., diltiazem, verapamil, erythromycin, fluconazole, grapefruit juice), CYP3A inducers (e.g., rifampin, phenobarbital, phenytoin, carbamazepine, St. John's Wort), P-glycoprotein (P-gp) inhibitors (e.g., cyclosporine), drugs metabolized by CYP2D6 (e.g., tricyclic antidepressants), digoxin, metformin, or other QT-prolonging drugs. If you are using any of these medications, your dose may need to be adjusted by your doctor.

Pregnancy and Breastfeeding:

Ranexa should only be used during pregnancy or breastfeeding if the potential benefits outweigh the risks and under strict medical supervision. It is not known if ranolazine passes into breast milk. Women who are pregnant, planning to become pregnant, or breastfeeding must discuss the risks and benefits with their doctor.

Use in Children:

Ranexa's safety and effectiveness in children have not been established. Talk to your doctor or pharmacist before using this medication in children.

Frequently Asked Questions about Ranexa at CanadaPharmacyOnline.com:

Why is Ranexa more affordable in Canada than in the United States?

Prescription drug prices, including Ranexa, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can the Ranexa tablet be split, crushed, or chewed?

No, Ranexa tablets are extended-release tablets and should be swallowed whole. Do not crush, break, or chew the tablets.

Can I take Ranexa with food?

Ranexa can be taken with or without food.

What should I do if I miss a dose of Ranexa?

If you miss a dose, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and take your next dose at the regular time. Do not double your dose.

How long does it take for Ranexa to work?

Ranexa is a long-term treatment for chronic angina. It may take several weeks for you to experience the full benefits. Continue taking Ranexa as prescribed by your doctor.

How much is the shipping for Ranexa?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products, including Ranexa, if ordered.

How do I order Ranexa from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process for prescription medications like Ranexa, visit our How to Order page.

Is there a limit on how many tablets of Ranexa I can order at one time?

CanadaPharmacyOnline.com can typically dispense a maximum of a three-month supply of Ranexa at once, per your doctor's valid prescription and in accordance with Canadian regulations.

Can Ranexa be bought over the counter?

No, Ranexa is a prescription medication that requires a valid doctor's prescription. We do not sell this product without a valid prescription.

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News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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