Tarka (Trandolapril/Verapamil SR)

Name: Tarka
Brand: Abbott
SKU: 2419
Availability: InStock

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Qty-Price (USD)

Type:

Product: Tarka

Manufacturer: Abbott

Country: Turkey

Dosage: 2 mg/180 mg

Qty-Price (USD):

Generic Equivalent of Tarka

Type

Product

Manufacturer

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There is no generic product of Tarka.

Tarka Information

Tarka at CanadaPharmacyOnline.com

Tarka (trandolapril/verapamil hydrochloride extended-release) was originally manufactured by Abbott. The current holder of the brand name is Viatris Canada. It is available in many countries worldwide, including Turkey.

The generic trandolapril/verapamil extended-release tablets are currently unavailable (at this pharmacy).

Dosage:

Tarka (trandolapril/verapamil hydrochloride ER) is available in the following oral strengths:
• Extended-release tablets: 2 mg trandolapril/180 mg verapamil.

The usual dose is one tablet once daily with food or immediately after a meal. Tarka should not be used for initial therapy. Dosage is individualized and based on blood pressure response.

Usage:

Tarka (trandolapril/verapamil ER) is a combination of an ACE inhibitor and a calcium channel blocker indicated for the treatment of hypertension in patients for whom combination therapy is appropriate. Trandolapril is an ACE inhibitor that relaxes blood vessels by blocking the conversion of angiotensin I to angiotensin II. Verapamil ER is a non-dihydropyridine calcium channel blocker that lowers blood pressure and, in its sustained-release form at this dose, also has rate-slowing effects. Together, they provide complementary antihypertensive mechanisms.

Mechanism of Action
Trandolapril, the active ingredient in Tarka, is a prodrug that is converted in the body to the active ACE inhibitor, trandolaprilat. Trandolaprilat blocks ACE, reducing angiotensin II production. This relaxes blood vessels and reduces aldosterone-mediated fluid retention. Verapamil blocks calcium channels in cardiac and vascular smooth muscle cells, reducing cardiac contractile force, slowing AV conduction, and relaxing blood vessels. Because verapamil, in this context, also slows the heart rate, it partially offsets any reflex tachycardia that can sometimes occur with other antihypertensives. ACE inhibitors can cause a dry cough in some patients due to bradykinin accumulation.

Take Tarka exactly as your doctor prescribes, as outlined in the Product Monograph. Swallow whole. Do not crush, split, or chew the tablets, as doing so destroys the extended-release mechanism and releases a dangerous dose of verapamil all at once. Take this medicine with food. Do not stop suddenly.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Tarka, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Tarka (trandolapril/verapamil ER). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Tarka; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Constipation
• Dizziness
• Dry, persistent cough
• Fatigue
• Headache
• Nausea
• Slow heartbeat

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Angioedema: Swelling of the face, lips, tongue, or throat. Stop Tarka immediately and seek emergency care.
• Heart Block or Severe Bradycardia: Very slow pulse, dizziness, or fainting (from verapamil).
• Heart Failure: Worsening breathlessness, sudden weight gain, or severe swelling.
• High Potassium (Hyperkalemia): Muscle weakness or irregular heartbeat (from trandolapril).
• Low Blood Pressure (Hypotension): Severe dizziness or fainting, especially after the first dose.
• Worsening Kidney Function: Decreased urine output or sudden swelling.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Tarka, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Tarka/trandolapril/verapamil ER if:
• Allergies: Known hypersensitivity to trandolapril, verapamil, any ACE inhibitor, or any ingredient.
• Angioedema History: History of angioedema with any ACE inhibitor, or hereditary/idiopathic angioedema.
• Diabetes with Aliskiren: ACE inhibitors must not be combined with aliskiren in patients with diabetes.
• Heart Block or Severe Bradycardia (without a pacemaker), cardiogenic shock, sick sinus syndrome, severe hypotension.
• Sacubitril/Valsartan (Entresto): Do not take Tarka within 36 hours of switching to or from sacubitril/valsartan.

Tell your doctor about all of your medical conditions, past and present, before starting Tarka. This is crucial as certain conditions affect the drug's safety.
• Diabetes
• Heart disease
• If you are on a low-salt diet.
• Kidney disease
• Liver disease

Abrupt Withdrawal Warning:
Do not stop taking Tarka suddenly. The verapamil component must be withdrawn gradually under medical supervision to avoid rebound effects.

Drug Interactions:

Before taking Tarka, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please refer to the consumer information at https://www.viatris.ca/-/media/project/common/viatrisca/pdf/brand-and-speciality/tarkapi.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Tarka. Tarka may interact with other medicines, including but not limited to:
• Beta-blockers: Additive depression of heart rate and AV conduction with the verapamil component; use with caution under specialist supervision.
• Cyclosporine: Verapamil raises cyclosporine levels; monitor closely.
• Digoxin: Verapamil raises digoxin levels and further slows the heart rate; monitor digoxin levels and pulse.
• Diuretics: May cause excessive blood pressure lowering with the first dose of Tarka.
• Grapefruit: Avoid eating grapefruit or drinking grapefruit juice while taking Tarka. Grapefruit significantly increases verapamil levels in your blood, raising the risk of severe toxicity.
• Lithium: Both ACE inhibitors and verapamil can raise lithium levels; concurrent use is generally not recommended.
• NSAIDs: May reduce the antihypertensive effect of trandolapril and worsen kidney function.
• Potassium supplements or potassium-sparing diuretics may raise potassium levels to dangerous levels.

Pregnancy and Breastfeeding:

Tarka is contraindicated during pregnancy. ACE inhibitors can cause serious harm or death to an unborn baby when used in the second or third trimester. Stop Tarka immediately if pregnancy is detected and contact your doctor. Breastfeeding is not recommended while taking Tarka. Discuss the risks and benefits with your doctor.

Use in Children:

The safety and efficacy of Tarka in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Tarka at Canada Pharmacy Online

Why is Tarka more affordable in Canada than in the United States?

Prescription drug prices, including Tarka, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Tarka I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Tarka per your doctor’s prescription.

Can I buy Tarka from you over the counter?

No, Tarka requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Tarka?

No, the generic alternative is not available (at this pharmacy).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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