Zestril (Lisinopril)

Name: Zestril
Brand: AstraZeneca
SKU: 2749
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Zestril

Manufacturer: AstraZeneca

Country: Australia

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Zestril

Manufacturer: AstraZeneca

Country: Australia

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Zestril (ON BACKORDER)

Manufacturer: AstraZeneca

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Zestril

Manufacturer: AstraZeneca

Country: Australia

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Zestril

Manufacturer: AstraZeneca

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Generic Equivalent of Zestril

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Lisinopril

Manufacturer: Generic

Country: United Kingdom

Dosage: 2.5 mg

Qty-Price (USD):

Type:

Product: Lisinopril

Manufacturer: Generic

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Lisinopril

Manufacturer: Generic

Country: United Kingdom

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Lisinopril

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Lisinopril

Manufacturer: Generic

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Lisinopril

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Lisinopril

Manufacturer: Generic

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Lisinopril

Manufacturer: Generic

Country: United States

Dosage: 40 mg

Qty-Price (USD):

Zestril Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on January 9, 2026.

Zestril and Lisinopril at CanadaPharmacyOnline.com

Lisinopril was originally discovered and developed by Merck Sharp & Dohme (MSD). The Zestril brand name was established through a co-marketing agreement with AstraZeneca (formerly Zeneca), which allowed both companies to market the drug under different names (Merck used the name Prinivil). In March 2020, AstraZeneca completed the divestment of the global commercial rights for Zestril to Atnahs Pharma, which rebranded globally as Pharmanovia in 2021. Today, Pharmanovia markets brand-name Zestril in the United Kingdom, Australia, and many other global markets.

Generic lisinopril is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturers of your dispensed medication may vary.

Important Information about Generic Lisinopril

Generic lisinopril contains the same active ingredient as brand-name Zestril and must meet the same effectiveness and quality standards. This means it is designed to work in the same way as Zestril. Studies have shown that generic lisinopril is bioequivalent to brand-name Zestril, meaning it has similar absorption and achieves comparable blood concentrations. Individual responses to lisinopril can vary due to factors such as kidney function (renal clearance), intestinal absorption, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

At this pharmacy, Zestril is available in strengths of 5 mg, 10 mg, and 20 mg oral tablets.

Generic lisinopril is also available in 2.5 mg and 40 mg tablet strengths.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Zestril (lisinopril) is a prescription medication that effectively lowers high blood pressure in adults and children 6 years and older by relaxing and widening blood vessels. Beyond managing hypertension to help prevent strokes and heart attacks, Zestril is also used to treat heart failure and is frequently prescribed after a heart attack to help improve survival and protect the heart muscle from further damage.

Mechanism of Action:
Lisinopril belongs to a class of medications called ACE inhibitors, which primarily treat high blood pressure and heart failure. Unlike many other drugs in this class, lisinopril is not a "prodrug," meaning it does not require activation by the liver; instead, it enters the body in its active form and is eventually excreted unchanged by the kidneys. Blocking the production of a hormone that constricts blood vessels allows blood vessels to relax and widen, lowering blood pressure and reducing the overall workload on the heart.

Take Zestril exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult a doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Zestril, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Zestril (lisinopril). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Zestril; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Cough (persistent and dry)
• Dizziness
• Headache
• Hypotension (low blood pressure)

Other Potential Side Effects (less common):
• Diarrhea
• Fatigue
• Nausea
• Skin Rash
• Upset Stomach
• Unusual Tiredness

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Angioedema: Rapid swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing.
• Kidney Issues: A significant decrease in the amount of urine, or swelling in your feet and ankles.
• Liver Problems: Yellowing of the skin or eyes (jaundice), dark urine, or severe right-sided abdominal pain.
• Signs of High Potassium (Hyperkalemia): Muscle weakness, tingling sensations, or a slow/irregular heartbeat.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Zestril, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Zestril (lisinopril) if you have the following conditions:
• Aliskiren Use: You have diabetes or renal impairment and are taking medications containing aliskiren.
• Allergy: You are allergic to lisinopril or any other ACE inhibitor (like enalapril, ramipril, etc.).
• History of Angioedema: if you ever had a severe swelling reaction (face, lips, tongue, or throat), whether an ACE inhibitor caused it or was hereditary/idiopathic.
• Neprilysin Inhibitors: You have taken a medication containing sacubitril (e.g., Entresto) within the last 36 hours. Using these together significantly increases the risk of life-threatening swelling.
• Pregnancy: You are pregnant or planning to become pregnant. Zestril can cause serious injury or death to a developing fetus.

Tell your doctor about all medical conditions, especially:
• Autoimmune Conditions: Like lupus or scleroderma, which may increase the risk of blood cell changes.
• Diabetes: Because Zestril can occasionally affect blood sugar levels or interact with other diabetes medications.
• Electrolyte Imbalances: Specifically, if you have a history of high potassium (hyperkalemia) or are on a low-salt diet using potassium-based salt substitutes.
• Heart Valve Problems: Such as aortic stenosis.
• Kidney Disease: Including renal artery stenosis or being on dialysis.
• Liver Disease: To ensure your body can metabolize medications safely.
• Planned Surgery: Especially if it involves general anesthesia.

Drug Interactions:

Before taking Zestril, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the Details for Zestril - Drug and Health Products Portal at https://dhpp.hpfb-dgpsa.ca/dhpp/resource/17215.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Zestril.

Important Drug Interactions for Zestril
• Angioedema (Severe Swelling) Risk:
o Neprilysin Inhibitors (e.g., Entresto): You must wait at least 36 hours between taking Zestril and any medication containing sacubitril. Using them together creates a high risk of life-threatening swelling of the face and throat.
o mTOR Inhibitors (e.g., Everolimus, Sirolimus): These cancer or transplant medications can also increase the likelihood of a severe swelling reaction when combined with an ACE inhibitor.
• Blood Sugar & Toxicity:
o Diabetes Medications: Zestril can increase sensitivity to insulin or sulfonylureas (like glipizide). You should monitor closely for signs of hypoglycemia (low blood sugar).
o Lithium: Zestril prevents the kidneys from clearing lithium properly, which can cause the drug to build up to toxic levels in your blood.
• Dual Blockade:
o ARBs or Aliskiren: Combining Zestril with other drugs that block the same hormonal system (like losartan or aliskiren) is generally avoided as it increases the risk of kidney failure and low blood pressure without extra benefit.
• Kidney Function & The "Triple Whammy":
o NSAIDs (e.g., Ibuprofen, Naproxen, Celebrex): These can reduce lisinopril’s effectiveness and significantly increase the risk of acute kidney injury.
o The Triple Whammy: This occurs when you combine Zestril + a Diuretic ("water pill") + an NSAID. This combination is a major cause of sudden kidney strain.
• Potassium & Heart Rhythm:
o Potassium-Sparing Agents: Avoid potassium supplements and salt substitutes that use potassium instead of sodium. Because lisinopril causes the kidneys to retain potassium, combining these medications can lead to hyperkalemia (dangerously high potassium), which can stop the heart.

Pregnancy and Breastfeeding:

Using Zestril (lisinopril) during pregnancy is strictly avoided because it can cause severe injury or even death to a developing baby, particularly in the second and third trimesters. If you discover you are pregnant, contact your doctor immediately to transition to a safer alternative; do not stop taking your blood pressure medication until your doctor has provided a replacement plan. Regarding breastfeeding, it is not yet fully known if lisinopril passes into human breast milk. However, due to the risk of low blood pressure or kidney issues in a nursing infant, doctors generally recommend using an alternative treatment with a better-established safety profile for breastfeeding, such as enalapril or captopril.

Use in Children:

For children who have difficulty swallowing pills, the medication can be prepared as a customized oral suspension by a pharmacist (ready-to-use solutions may be available via specific international sourcing. Zestril is not recommended for children under 6 years of age, or for any child with significant kidney problems, specifically a glomerular filtration rate (GFR) less than 30 mL/min/1.73 m2, as its safety and effectiveness have not been established in these groups.

Frequently Asked Questions about Zestril at Canada Pharmacy Online

Why is Zestril more affordable in Canada than in the United States?

Prescription drug prices, including Zestril, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a limit on how many Zestril tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Zestril at one time, per your doctor's prescription.

Can I buy Zestril over the counter from you?

No, Zestril requires a valid prescription from your doctor. We do not sell this product without a prescription.

Blog Post:

Natural Ways to Lower Your Blood Pressure

Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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