Zestoretic (Lisinopril/HCTZ)

Name: Zestoretic
Brand: Generic
SKU: 2226
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Zestoretic.

Generic Equivalent of Zestoretic

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Lisinopril/HCTZ

Manufacturer: Generic

Country: Canada

Dosage: 10 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Lisinopril/HCTZ

Manufacturer: Generic

Country: United Kingdom

Dosage: 10 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Lisinopril/HCTZ

Manufacturer: Generic

Country: Canada

Dosage: 20 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Lisinopril/HCTZ

Manufacturer: Generic

Country: Canada

Dosage: 20 mg/25 mg

Qty-Price (USD):

Type:

Product: Lisinopril/HCTZ

Manufacturer: Generic

Country: United Kingdom

Dosage: 20 mg/12.5 mg

Qty-Price (USD):

Zestoretic Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on June 23, 2026.

Lisinopril/hydrochlorothiazide at CanadaPharmacyOnline.com

The current holder of the Canadian authorization for brand-name Zestoretic (lisinopril/hydrochlorothiazide) is Searchlight Pharma Inc. The brand Zestoretic is unavailable (at this pharmacy).

Generic lisinopril/hydrochlorothiazide is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards. Generic lisinopril/hydrochlorothiazide is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Lisinopril/hydrochlorothiazide

Generic lisinopril/hydrochlorothiazide contains the same active ingredient as brand-name Zestoretic. It must meet the same effectiveness and quality standards. This means it is designed to work like Zestoretic. Studies have shown that generic lisinopril/hydrochlorothiazide is bioequivalent to brand-name Zestoretic, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Lisinopril/hydrochlorothiazide is available in the following oral strengths at this pharmacy:
• Tablets: 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg.

The dose is one tablet taken once daily, with or without food. Zestoretic is not intended as initial therapy. Dosage is individualized and based on response to treatment.

Usage:

Zestoretic (lisinopril/hydrochlorothiazide) is indicated for the treatment of hypertension in patients for whom combination therapy is appropriate. Lisinopril is an ACE inhibitor that relaxes blood vessels by blocking the conversion of angiotensin I to angiotensin II. Hydrochlorothiazide is a thiazide diuretic that reduces blood volume by increasing the excretion of sodium and water in the urine. Together, they lower blood pressure more effectively than either agent alone through complementary mechanisms.

Mechanism of Action
Lisinopril, one of the active ingredients in Zestoretic, works by reducing the production of angiotensin II. This causes blood vessels to relax and reduces aldosterone-driven fluid retention, lowering blood pressure. Hydrochlorothiazide (HCTZ) inhibits sodium and chloride reabsorption in the kidneys, increasing urinary excretion of salt and water. This reduces blood volume, which lowers blood pressure. HCTZ also activates the RAAS as a compensatory response, but lisinopril simultaneously blocks this, making the combination synergistic. HCTZ can cause potassium loss, which lisinopril partially offsets by reducing aldosterone.

Take Zestoretic exactly as your doctor prescribes, as directed in the Product Monograph. Take once daily with or without food.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Zestoretic, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Zestoretic (lisinopril/hydrochlorothiazide). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Zestoretic; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Cough
• Dizziness or headache
• Fatigue
• Increased urination
• Muscle cramps due to electrolyte changes
• Nausea or stomach upset.

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Acute Angle-Closure Glaucoma: Sudden blurred vision or severe eye pain (from HCTZ). Medical emergency; stop Zestoretic immediately.
• Angioedema: Swelling of the face, lips, tongue, or throat. Stop Zestoretic immediately and seek emergency care.
• High Potassium (Hyperkalemia): Muscle weakness or irregular heartbeat.
• Low Blood Pressure (Hypotension): Severe dizziness or fainting, especially after the first dose.
• Low Potassium (Hypokalemia): Muscle cramps, weakness, or irregular heartbeat.
• Non-Melanoma Skin Cancer: Long-term HCTZ use increases risk. Inspect skin regularly and protect it from sunlight.
• Worsening Kidney Function: Decreased urine output or rapid swelling.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Zestoretic, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Zestoretic/lisinopril/hydrochlorothiazide if:
• Allergies: Known hypersensitivity to lisinopril, hydrochlorothiazide, sulfonamide-derived drugs, any ACE inhibitor, or any ingredient.
• Angioedema History: History of angioedema with any ACE inhibitor, or hereditary/idiopathic angioedema.
• Anuria.
• Pregnancy.
• Sacubitril/Valsartan (Entresto): Do not take Zestoretic within 36 hours of switching to or from sacubitril/valsartan.

Tell your doctor about all of your medical conditions, past and present, before starting Zestoretic. This is crucial as certain conditions affect the drug's safety.
• Diabetes
• Gout
• If you are on a low-salt diet.
• Kidney disease
• Liver disease

Drug Interactions:

Before taking Zestoretic, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the product monograph at https://pdf.hres.ca/dpd_pm/00062485.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Zestoretic. Zestoretic may interact with other medicines, including but not limited to:
• Aliskiren: Contraindicated in patients with diabetes or renal impairment (GFR less than 60 mL/min/1.73m2).
• Antidiabetic agents: ACE inhibitors may enhance blood glucose-lowering. Monitor glucose closely.
• Diuretics: May cause excessive blood pressure lowering with the first dose.
• Lithium: Both lisinopril and HCTZ raise lithium levels; concurrent use is generally not recommended.
• mTOR inhibitors (e.g., sirolimus, everolimus): Increased risk of angioedema.
• NSAIDs: May reduce the antihypertensive effect and worsen kidney function.
• Potassium supplements or potassium-sparing diuretics: Risk of hyperkalemia with the lisinopril component.

Pregnancy and Breastfeeding:

Zestoretic is contraindicated during pregnancy. ACE inhibitors used in the second and third trimesters are known to cause serious fetal harm. Stop Zestoretic immediately if pregnancy is detected. Lisinopril has been detected in breast milk. Breastfeeding is not recommended while taking Zestoretic. Discuss the risks and benefits with your doctor.

Use in Children:

The safety and efficacy of Zestoretic in patients under 18 years of age have not been established. It is not recommended for use in children.

Frequently Asked Questions about Zestoretic at Canada Pharmacy Online

Why is Zestoretic more affordable in Canada than in the United States?

Prescription drug prices, including Zestoretic, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Zestoretic I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Zestoretic per your doctor’s prescription.

Can I buy Zestoretic from you over the counter?

No, Zestoretic requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Zestoretic?

Yes, generic lisinopril/hydrochlorothiazide is available at this pharmacy.

Blog Post:

Natural Ways to Lower Your Blood Pressure

Latest News:

For High Blood Pressure, One Minute of Intense Exercise May Be Safer Than Longer Bouts (news published June 10, 2026)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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