Climara Patch (Estradiol Hemihydrate)

Name: Climara Patch
Brand: Bayer
SKU: 0244
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Climara Patch

Manufacturer: Bayer

Country: Canada

Dosage: 25 mcg

Qty-Price (USD):

Type:

Product: Climara Patch

Manufacturer: Bayer

Country: Canada

Dosage: 50 mcg

Qty-Price (USD):

Type:

Product: Climara Patch

Manufacturer: Bayer

Country: Canada

Dosage: 75 mcg

Qty-Price (USD):

Type:

Product: Climara Patch (ON BACKORDER)

Manufacturer: Bayer

Country: Australia

Dosage: 75 mcg

Qty-Price (USD):

Generic Equivalent of Climara Patch

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no generic product of Climara Patch.

Climara Patch Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on June 6, 2025.

Climara Patch at CanadaPharmacyOnline.com

Brand Climara (Estradiol Hemihydrate), manufactured by Bayer, is available in Canada and Australia.

Generic estradiol hemihydrate is currently unavailable (at this pharmacy).

Dosage:

Climara is a transdermal patch available in the following strengths (at this pharmacy):
• 25 mcg (delivers 0.025 mg of estradiol)
• 50 mcg (delivers 0.05 mg of estradiol)
• 75 mcg (delivers 0.075 mg of estradiol)

Your doctor will determine the appropriate dose and treatment duration based on your needs and condition.

Usage:

Climara (estradiol hemihydrate) is prescription medication used to help women find relief from common menopause symptoms like hot flashes, night sweats, vaginal dryness, and mood swings. Climara patches can also help prevent bone thinning (osteoporosis) after menopause.

For more information, please refer to the product labeling information: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020375s026lbl.pdf

Mechanism of Action:
Climara patches work by delivering estradiol, a natural estrogen hormone, directly through your skin and into your bloodstream. This steady supply of estrogen helps to replace the hormone levels that decrease during menopause or due to other medical conditions. Once in your body, the estradiol attaches to special “receptor” sites in various tissues, including your brain (to help with hot flashes), vagina (to relieve dryness), and bones (to prevent bone loss). By replenishing these estrogen levels, Climara helps to reduce menopausal symptoms and protect against bone thinning.

Take Climara exactly as your doctor prescribes. Follow the instructions in the product monograph | Bayer, https://www.bayer.com/sites/default/files/2020-11/climara-pm-en.pdf. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Climara, discussing all possible aspects with your doctor or pharmacist is essential.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Climara, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects: These are some examples of common side effects of Climara, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Application site reactions: Redness, irritation, itching, or rash where the patch is applied. Rotating the patch site can help.
• Breast pain or tenderness: This is a very common side effect of estrogen therapy.
• Changes in menstrual bleeding patterns: This can include spotting or breakthrough bleeding, especially in the first few months of treatment.
• Hair loss or thinning.
• Headache: Mild to moderate headaches.
• Fluid retention (edema): Swelling in the hands, ankles, or feet.
• Mood changes: Including depression or irritability
• Nausea, stomach cramps, bloating: Digestive discomfort.
• Vaginal discharge or yeast infections.
• Weight changes: Either gain or loss

Serious or rare side effects: Stop taking Climara and seek immediate medical attention if you experience any of the following:
• Blood Clots: Estrogen therapy, including transdermal patches, can increase the risk of blood clots in the legs (deep vein thrombosis), lungs (pulmonary embolism), brain (stroke), or heart (heart attack). Symptoms include sudden chest pain, shortness of breath, sudden severe headache, slurred speech, sudden vision changes, or pain/swelling/warmth in an arm or leg.
• Breast cancer: A slight increase in risk, especially with long-term combined estrogen-progestin therapy. Regular breast exams and mammograms are important.
• Certain Cancers: Estrogen therapy can increase the risk of developing certain cancers.
• Dementia: The Women's Health Initiative (WHI) study indicated an increased risk of probable dementia in postmenopausal women 65 years or older using combined HRT. This is an important consideration for older users.
• Endometrial cancer (cancer of the uterus lining): This risk is significantly reduced or eliminated if a progestin is also taken (which is usually the case for women with an intact uterus). Any unusual vaginal bleeding (especially after menopause) should be reported immediately.
• Gallbladder problems: Symptoms include severe stomach pain, nausea, vomiting, or fever.
• Increased Blood Pressure: Estrogen can increase blood pressure in some individuals.
• Liver problems: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea/vomiting.
• Ovarian cancer: Some studies suggest a possible increased risk.
• Severe Allergic Reactions: Signs include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Climara.

Climara should not be used if:

Active or History of Blood Clots or Thromboembolic Disorders:
• Deep Vein Thrombosis (DVT): A blood clot in a deep vein, usually in the leg.
• Pulmonary Embolism (PE): A blood clot that travels to the lungs.
• Arterial Thromboembolic Disease: Such as a recent heart attack (myocardial infarction) or stroke. Estrogen therapy increases the risk of these serious blood clotting events.

Active or Severe Liver Disease: Including liver dysfunction where liver function tests have not returned to normal, or a history of liver tumors (benign or malignant). Estrogen is metabolized by the liver, and impaired liver function can lead to increased estrogen levels or worsen liver conditions.

Hypersensitivity/Allergy: A known allergy to estradiol or any other ingredients in the Climara patch formulation.

Known or Suspected Pregnancy or Lactation (Breastfeeding): Climara patches are not for use during pregnancy as they may harm the developing baby, and estrogens can pass into breast milk, potentially affecting the infant.

Known, Suspected, or History of Certain Cancers:
• Breast Cancer: Any known, suspected, or history of breast cancer. Estrogen can stimulate the growth of some breast cancers.
• Estrogen-Dependent Malignant Tumors: This includes certain cancers of the uterus (endometrial cancer) or ovaries that are known to be sensitive to estrogen.

Undiagnosed Abnormal Genital Bleeding: Any unusual vaginal bleeding that has not been evaluated by a doctor. This is a critical contraindication because it could be a sign of endometrial cancer, which estrogen therapy can worsen.

Drug Interactions:

Before taking Climara, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Climara prescribing information | BayerHealthCare.com: https://labeling.bayerhealthcare.com/html/products/pi/Climara_PI.pdf

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements.

Climara may interact with other medicines, including:
• Enzyme-Inducing Medications: Some medications can speed up the metabolism of estradiol in the liver, leading to lower levels of estrogen in your body. This can reduce the effectiveness of Climara and potentially lead to a return of menopausal symptoms or a decrease in bone protection. Examples include:
o Certain anticonvulsants/anti-seizure medications: Such as carbamazepine, phenobarbital, and phenytoin.
o Rifampin: An antibiotic used to treat tuberculosis.
o St. John's Wort: A herbal supplement often used for depression.
o Some HIV medications: Such as ritonavir and nelfinavir.

• Enzyme-Inhibiting Medications: Conversely, some medications can slow down the metabolism of estradiol, potentially leading to higher levels of estrogen in your body and an increased risk of estrogen-related side effects. Examples include:
o Certain antifungal medications: Such as ketoconazole and itraconazole.
o Certain macrolide antibiotics: Such as erythromycin and clarithromycin.

• Thyroid Hormone Replacement Therapy: If you are taking thyroid hormone replacement (e.g., levothyroxine), estrogen therapy can increase the need for thyroid hormone. Your doctor may need to monitor your thyroid levels and adjust your thyroid medication dose.

• Corticosteroids: Estrogens can increase the effects of corticosteroids. If you are taking corticosteroids, your doctor may need to adjust your dosage.

• Drugs for Diabetes: Estrogen might affect glucose tolerance, potentially altering the effectiveness of diabetes medications. Diabetics on Climara may require closer monitoring of their blood sugar levels and possible adjustments to their antidiabetic medication.

• Oral Anticoagulants (Blood Thinners): Estrogens can affect clotting factors. While transdermal patches are generally considered to have a lower risk of blood clots than oral estrogens, caution is still advised when used with blood thinners like warfarin. Close monitoring of clotting times (e.g., INR) may be necessary.

• Aromatase Inhibitors, SERMs, and other anti-estrogens: Medications used to treat certain cancers (e.g., breast cancer) or for other purposes (e.g., tamoxifen, raloxifene, anastrozole, exemestane, letrozole) work by blocking or reducing estrogen activity. Using them with Climara would counteract Climara's intended effect and is generally contraindicated or not recommended.

Pregnancy and Breastfeeding:

Climara is not safe for use during pregnancy because the hormones it delivers can potentially harm the developing baby. If someone becomes pregnant while using Climara, they should remove the patch immediately and contact their doctor. For breastfeeding mothers, the estradiol from Climara can pass into breastmilk. While the amount might be small from a patch, estrogen can reduce both the amount and quality of breast milk. Climara is not advised for those who are breastfeeding. It is essential to discuss potential risks and benefits with your healthcare provider.

Use in Children:

Climara patches are generally not used in children and are not recommended for this age group. The patches deliver estrogen, a hormone primarily used to address adult female health concerns like menopause. Their safety and effectiveness have not been thoroughly studied in children, and introducing external hormones could interfere with a child's natural growth and development, including puberty. While estrogen might be used in highly specialized situations for specific pediatric medical conditions (like delayed puberty), this would involve very careful, low-dose management by a specialist, and typically not with standard Climara patches.

Frequently Asked Questions about Climara at CanadaPharmacyOnline.com:

Why is Climara more affordable in Canada than in the United States?

Prescription drug prices, including Climara, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can I buy over the counter from you?

No, Climara requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

Blog Posts

Easy, Inexpensive Methods to Stave Off Menopause
Estradiol Patch from Sandoz Canada

News:

The Market For Menopause Products is Booming- But There’s An Easy Way To Find What Actually Works (article published on April 16, 2025)

Similar Drugs in the category of Menopausal Hormone Therapy:

Estring Vaginal Ring Premarin Vagifem Vivelle Dot Premarin Vaginal Cream

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers