Dovato (Dolutegravir Sodium/Lamivudine)

Name: Dovato
Brand: ViiV Healthcare
SKU: 7619
Availability: InStock

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Qty-Price (USD)

Type:

Product: Dovato Tablet

Manufacturer: ViiV Healthcare

Country: Canada

Dosage: 50 mg/300 mg

Qty-Price (USD):

Generic Equivalent of Dovato

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There is no generic product of Dovato.

Dovato Information

Dovato at CanadaPharmacyOnline.com

Brand Dovato (dolutegravir sodium/lamivudine) is manufactured by ViiV Healthcare in many countries worldwide, including Canada.

The generic dolutegravir sodium/lamivudine is currently unavailable (at this pharmacy).

Dosage:

Dovato is commonly available as 50 mg/300 mg oral tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Dovato (dolutegravir sodium/lamivudine) is a prescription medication primarily used to treat human immunodeficiency virus type 1 (HIV-1) infection in adults and certain adolescents. It is prescribed for patients weighing at least 40 kg. HIV is a virus that attacks the immune system, specifically CD4 cells, which are essential for fighting infections. Without treatment, HIV weakens the immune system and increases the risk of serious illness. Dovato helps reduce the amount of virus in the body, protects the immune system, and slows disease progression. Dovato is only a complete regimen for patients with no known or suspected resistance to its ingredients. Before starting, your doctor will confirm that you do not have a history of resistance (e.g., the M184V mutation) and will test you for Hepatitis B, as Dovato requires special supervision for patients with co-infections.

Mechanism of Action:
Dovato (dolutegravir sodium/lamivudine) is a combination of two antiretroviral medications that work in different ways to stop HIV from multiplying. Dolutegravir inhibits the enzyme integrase, which HIV requires to insert its genetic material into human cells. Lamivudine blocks reverse transcriptase, another enzyme HIV uses to make copies of itself. By targeting these key steps, Dovato lowers viral load and helps maintain immune health.

Take Dovato exactly as your doctor prescribes, following the instructions in the product monograph in Canada that accompanies the medication. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Dovato, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Dovato (dolutegravir sodium/lamivudine). It is not an exhaustive list, and individual reactions can vary. This information is for educational purposes and should not replace professional medical advice. Before starting Dovato, it is crucial to discuss possible side effects and risks with your doctor or pharmacist.

Common side effects: These are common side effects of Dovato; other side effects are possible. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Diarrhea
• Fatigue
• Headache
• Nausea
• Trouble sleeping

Serious or rare side effects- Seek immediate medical attention or call emergency services if you experience any of the following:
• Mood changes.
• Severe abdominal pain.
• Signs of an allergic reaction, such as swelling, breathing difficulties, swelling of the face, lips, or throat (Seek immediate help if you experience a rash accompanied by fever, general malaise, extreme tiredness, or muscle/joint aches. This can indicate a severe hypersensitivity reaction that requires immediate and permanent discontinuation of the drug.
• Signs of liver problems, including yellowing of the skin or eyes

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Dovato, it is essential to discuss all your medical conditions, past and present, as well as all medications you are currently taking, with your doctor or pharmacist.

Dovato should not be used if:
• You have a known allergy to dolutegravir sodium/lamivudine or any of the ingredients in the medication
• You are taking Dofetilide (a heart rhythm medication)

Tell your doctor about all of your medical conditions, past and present, before starting Dovato. This is crucial because certain conditions can affect whether Dovato is right for you. These conditions may include, but are not limited to:
• Kidney problems
• Liver disease, including hepatitis B (Dovato contains a "Boxed Warning" for patients co-infected with HIV-1 and Hepatitis B (HBV). If you have HBV and stop taking Dovato, your Hepatitis B may suddenly "flare" or worsen, leading to severe liver damage. Do not stop taking this medication without strict medical supervision if you have HBV.)
• Mental health conditions, such as depression or anxiety

Drug Interactions:

Before taking Dovato, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information from GSK at https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Dovato/pdf/DOVATO-PI-PIL.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Dovato. Dovato may interact with other medicines, but is not limited to:
• Antacids and mineral supplements – These bind to dolutegravir, significantly reducing its absorption. Take aluminium- or magnesium-containing products at least 2 hours before or 6 hours after Dovato. If you take Dovato with a meal, you may take calcium or iron supplements concurrently.
• Certain seizure medications, such as carbamazepine, phenytoin, phenobarbital, and oxcarbazepine, can reduce dolutegravir levels and make Dovato less effective.
• Dofetilide – Must not be used with Dovato. Dolutegravir increases dofetilide levels, which can cause dangerous heart rhythm problems.
• Metformin – Dolutegravir can increase metformin blood levels, raising the risk of side effects such as stomach upset or low blood sugar. (If you are taking Metformin for diabetes, your doctor may need to limit your Metformin dose to a maximum of 1,000 mg per day. Dolutegravir significantly increases Metformin levels in the blood, which increases the risk of lactic acidosis.)
• Other lamivudine-containing medicines – Using multiple products containing lamivudine can lead to overdose and increased side effects.
• Rifampin, rifabutin, and rifapentine – These medicines lower dolutegravir levels and may reduce HIV control. Dose adjustments or alternative HIV regimens may be necessary.
• St. John's wort may lower dolutegravir levels and should not be used with Dovato.

Pregnancy and Breastfeeding:

While dolutegravir-based triple-drug regimens (a combination of three medications) are a preferred treatment option during pregnancy, the two-drug combination found in Dovato (dolutegravir/lamivudine) is generally not recommended for starting treatment during pregnancy. Standard clinical guidelines prefer three-drug regimens to ensure maximum viral suppression during the physiological changes of pregnancy. If you are already taking Dovato and become pregnant, your doctor will weigh the risks and benefits of continuing the regimen versus switching to triple therapy.

Regarding breastfeeding, modern guidelines support it as an option if you keep a sustained undetectable viral load. However, you should be aware that the medication does pass into breast milk in small amounts. It is vital to continue your medication as prescribed to prevent transmission; however, your physician may recommend more frequent viral load monitoring and high-dose folic acid supplementation during this period.

Frequently Asked Questions about Dovato at Canada Pharmacy Online:

Why is Dovato more affordable in Canada than in the United States?

Prescription drug prices, including Dovato, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Dovato at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Dovato requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It typically takes 7-18 business days for your order to be delivered from our pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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