Votrient (Pazopanib)

Name: Votrient
Brand: Novartis
SKU: 6755
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Votrient Tablet (Limited Stock)

Manufacturer: Novartis

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Type:

Product: Votrient Tablet

Manufacturer: Novartis

Country: Australia

Dosage: 400 mg

Qty-Price (USD):

Type:

Product: Votrient Tablet (ON BACKORDER)

Manufacturer: Novartis

Country: India

Dosage: 400 mg

Qty-Price (USD):

Generic Equivalent of Votrient

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Pazopanib Tablet

Manufacturer: Generic

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Votrient Information

Votrient and Pazopanib at CanadaPharmacyOnline.com

The manufacturer of brand-name Votrient (pazopanib hydrochloride) is Novartis Pharmaceuticals. It is available in many countries worldwide, including Canada, Australia, and India.

Generic pazopanib is also available. The specific manufacturer of the dispensed medication may vary depending on pharmacy inventory. Generic pazopanib is sourced from manufacturers that meet applicable regulatory standards.

Important Information about Generic Pazopanib

Generic pazopanib contains the same active ingredient as brand-name Votrient. It must meet the same effectiveness and quality standards. This means it is designed to work like Votrient. Studies have shown that generic pazopanib is bioequivalent to brand-name Votrient, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit “Access to Generic Drugs in Canada | Canada.ca”.

Dosage:

Votrient (pazopanib hydrochloride) is available in the following oral strengths at this pharmacy:
• Tablets: 200 mg and 400 mg film-coated tablets

The standard starting dose for adults is 800 mg taken orally once daily. Dosage is subsequently individualized and based on tolerability.

Usage:

Votrient (pazopanib) is a multi-kinase inhibitor indicated for the first-line treatment of advanced renal cell carcinoma (RCC) and for the treatment of patients with advanced non-adipocytic soft tissue sarcoma (STS) who have previously received chemotherapy. It targets the growth of both cancer cells and the blood vessels that tumors need to survive.

Mechanism of Action
Pazopanib is a targeted therapy known as a "multi-kinase inhibitor" or an "angiogenesis inhibitor." It fights cancer by launching a two-pronged attack – starving the tumor and stopping its growth. Large tumors require an active network of new blood vessels to supply them with oxygen and nutrients to survive. Votrient blocks specific cellular signals (such as VEGFR and PDGFR) that tell your body to build new blood vessels, effectively starving the tumor's supply lines. Simultaneously, the drug interferes with internal cellular switches (such as c-Kit) that signal cancer cells to multiply, helping to slow or halt tumor growth altogether.

Take Votrient exactly as your oncologist prescribes, following the instructions in the highlights of the prescribing information. Take the medicine on an empty stomach (at least 1 hour before or 2 hours after a meal). Swallow tablets completely whole. Do not crush, chew, or split them.

If you miss a dose, take it as soon as you remember. However, if your next dose is less than 12 hours away, skip the missed dose completely and take your next scheduled dose at the normal time. Do not double the dose to make up for a missed one.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Votrient, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Votrient (pazopanib). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Votrient; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Diarrhea
• Fatigue and weakness
• Hair color changes (lightening/depigmentation)
• High blood pressure (hypertension)
• Nausea, vomiting, or decreased appetite
• Skin discoloration (hypopigmentation or peeling)
• Taste changes (dysgeusia)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Arterial Thromboembolism: Chest pain, sudden weakness, numbness, or difficulty speaking. Seek emergency care immediately.
• Bleeding or Hemorrhage: Coughing up blood, unusual bruising, or uncontrolled bleeding.
• Cardiac Dysfunction: Worsening breathlessness, ankle swelling, or reduced exercise tolerance. Cardiac function (including Left Ventricular Ejection Fraction, or LVEF) should be monitored.
• Gastrointestinal Perforation or Fistula: Sudden severe abdominal pain.
• Posterior Reversible Encephalopathy Syndrome (PRES): Headache, seizures, lethargy, confusion, or blindness.
• Severe Liver Toxicity (Hepatotoxicity): Jaundice, dark urine, right upper abdominal pain, or extreme fatigue. Pazopanib carries a Boxed Warning for severe, potentially fatal hepatotoxicity. Liver function tests [ALT, AST, and bilirubin] must be monitored prior to starting, every 2 weeks for the first 9 weeks, and then monthly or as clinically indicated.
• Thrombotic Microangiopathy (TMA): Characterized by a dangerous breakdown of red blood cells, low platelets, and kidney injury.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Votrient, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Votrient/pazopanib if:
• Allergies: Known hypersensitivity to pazopanib or any ingredient in the tablet.
• Severe hepatic impairment.

Tell your doctor about all of your medical conditions, past and present, before starting Votrient. This is crucial as certain conditions affect the drug's safety.
• Bleeding disorders
• Heart disease (including a history of prolonged QT interval or congenital long QT syndrome)
• Liver disease
• Plans for surgery. Votrient affects how the blood vessels form and can delay wound healing. You will need to stop taking this medication at least 14 days before any procedure. Do not restart for at least 14 days after major surgery and until adequate wound healing is confirmed.
• Thyroid problems (Hypothyroidism is a known side effect; thyroid functions must be monitored proactively).

Drug Interactions:

Before taking Votrient, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the product monograph at https://www.novartis.com/ca-en/sites/novartis_ca/files/votrient_scrip_e.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Votrient. Votrient may interact with other medicines, including but not limited to:
• CYP3A4 inducers (e.g., rifampicin, carbamazepine, St. John's Wort): Significantly reduce pazopanib levels; avoid use.
• CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir, grapefruit juice): Significantly increase pazopanib levels; avoid concurrent use.
• Drugs that prolong QT interval: Pazopanib itself prolongs QT; additive risk with other QT-prolonging drugs.
• Gastric Acid Reducing Agents (e.g., proton pump inhibitors such as omeprazole, H2 antagonists such as ranitidine, or antacids): Avoid concurrent use. These medications increase gastric pH, which significantly decreases pazopanib solubility and absorption, thereby reducing its effectiveness.
• Simvastatin: Combination increases the risk of elevated liver enzymes and myopathy; use with caution or avoid. (If a statin is required, look for alternatives that do not share the same high-risk profile when combined with pazopanib, under strict oncology guidance.

Pregnancy and Breastfeeding:

Votrient can cause harm to an unborn baby. Women of childbearing potential must use effective contraception during treatment and for at least 2 weeks after the last dose. Male patients with female partners of childbearing potential must use condoms during treatment and for at least 2 weeks after the last dose. Votrient must not be used during pregnancy. Breastfeeding is not recommended while taking Votrient and for at least 2 weeks after stopping treatment; discuss with your doctor.

Use in Children:

The safety and efficacy of Votrient in patients under 18 years of age have not been established. Votrient is strictly contraindicated in children under 2 years of age due to severe safety risks regarding organ growth and development disruption observed in animal models.

Frequently Asked Questions about Votrient at Canada Pharmacy Online

Why is Votrient more affordable in Canada than in the United States?

Prescription drug prices, including Votrient, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Votrient I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Votrient per prescription from your doctor.

Can I buy Votrient from you over the counter?

No, Votrient requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Votrient?

Yes, the generic pazopanib is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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